Articles

Scientific articles with relation to genetic research on the Faroe Islands
2014-15

Thomsen J.A., Lund A.M., Olesen J.H., Mohr M, Rasmussen J.
Is L-Carnitine Supplementation Beneficial in 3-Methylcrotonyl-CoA Carboxylase Deficiency?
JIMD Rep. 2015 Mar 3. [Epub ahead of print]

Rasmussen J, Nielsen OW, Janzen N, Duno M, Gislason H, Køber L, Steuerwald U, Lund AM.
Carnitine levels in 26,462 individuals from the nationwide screening program for primary carnitine deficiency in the Faroe Islands. J Inherit Metab Dis. 2014 Mar;37(2):215-22. doi: 10.1007/s10545-013-9606-2. Epub 2013 May 8.

Rasmussen J, Thomsen JA, Olesen JH, Lund TM, Mohr M, Clementsen J, Nielsen OW, Lund AM.
Carnitine Levels in Skeletal Muscle, Blood, and Urine in Patients with Primary Carnitine Deficiency During Intermission of l-Carnitine Supplementation. JIMD Rep. 2015;20:103-11. doi: 10.1007/8904_2014_398. Epub 2015 Feb 10.

Jan Rasmussen, Allan M. Lund, Lotte Risom, Flemming Wibrand, Hannes Gislason, Olav W. Nielsen, Lars Køber, Morten Duno.
Residual OCTN2 transporter activity, carnitine levels and symptoms correlate in patients with primary carnitine deficiency. Molecular Genetics and Metabolism Reports, Volume 1, 2014, Pages 241–248

Maria Skaalum Petersen, Ilaria Guella, Sara Bech, Emil Gustavsson, Matthew J. Farrer.
Parkinson’s disease, genetic variability and the Faroe Islands. Parkinsonism & Related Disorder, Volume 21, Issue 1, January 2015, Pages 75–78. doi:10.1016/j.parkreldis.2014.10.027

Joensen, P.
The Faroe Islands. Pract Neurol. 2015 Feb 3. pii: practneurol-2015-001085. doi: 10.1136/practneurol-2015-001085. [Epub ahead of print]

Joensen, P.
Myasthenia gravis incidence in a general North Atlantic isolated population.
Acta Neurol Scand. 2014 Oct;130(4):222-8. doi: 10.1111/ane.12270. Epub 2014 Jul 1.

Gregersen, N.,  Buttenschøn, H.N., Hedemand, A., Dahl, H.A.,  Kristensen, A.S., Clementsen B., Woldbye D.P., Koefoed P.,  Erhardt A., Kruse, T.A.,  Wang A.G., Børglum, A.D., Mors O.
Are TMEM genes potential candidate genes for panic disorder? Psychiatric Genetics: February 2014 – Volume 24 – Issue 1 – p 37–41. doi: 10.1097/YPG.0000000000000022

Binzer S, Imrell K, Binzer M, Kyvik KO, Hillert J, Stenager E.
High inbreeding in the Faroe Islands does not appear to constitute a risk factor for multiple sclerosis. Mult Scler. 2014 Nov 12. pii: 1352458514557305. [Epub ahead of print]

Als, Thomas Damm; Lescai, Francesco; Dahl, Hans Atli; Grove, Jakob; Demontis, Ditte; Wang, August G.; Andorsdottir, Gudrid; Biskopstø, Marjun; Johansen, Oddbjørg; Nyegaard, Mette; Bolund, Lars; Mors, Ole; Wang, Jun; Børglum, Anders.
Population Structure & Cryptic Relatedness of the isolated Population of the Faroe Islands. 2014. Poster session presented at XXII World Congress of Psychiatric Genetics, København, Danmark.

2011-13

Gronskov K, Dooley C. M, Ostergaard E., Kelsh R. N., Hansen L., Levesque M. P, Vilhelmsen, K Møllgård K, Stemple D.L, Rosenberg T.
Mutations in C10orf11, encoding a melanocyte differentiation gene, cause autosomal recessive Albinism. Am J Hum Genet. 2013 Mar 7;92(3):415-21. doi: 10.1016/j.ajhg.2013.01.006. Epub 2013 Feb 7.

Gal A, Rau I, El ML, et al.
Autosomal-recessive posterior microphthalmos is caused by mutations in PRSS56, a gene encoding a trypsin-like serine protease. Am J Hum Genet 2011;88:382-90.

Ostergaard E, Duno M, Batbayli M, et al.
A novel MERTK deletion is a common founder mutation in the Faroe Islands and is responsible for a high proportion of retinitis pigmentosa cases. Mol Vis 2011;17:1485-92.

Joensen, P.
Incidence of amyotrophic lateral sclerosis in the Faroe Islands. Acta Neurol Scand. 2012 Jul;126(1):62-6. doi: 10.1111/j.1600-0404.2011.01611.x. Epub 2011 Oct 29.

Joensen P.
Multiple sclerosis: variation of incidence of onset over time in the Faroe Islands.
Mult Scler. 2011 Aug 26. No abstract available. PMID:21873517

Joensen P.
Multiple sclerosis: variation of incidence of onset over time in the Faroe Islands. Mult Scler. 2011

2000-2010

Pedersen RS, Brasch-Andersen C, Sim SC, Bergmann TK, Halling J, Petersen MS, Weihe P, Edvardsen H, Kristensen VN, Brøsen K, Ingelman-Sundberg M.
Linkage disequilibrium between the CYP2C19*17 allele and wildtype CYP2C8 and CYP2C9 alleles: identification of CYP2C haplotypes in healthy Nordic populations. Eur J Clin Pharmacol. 2010 Dec;66(12):1199-205.

Ostergaard E, Batbayli M, Duno M, et al.
Mutations in PCDH21 cause autosomal recessive cone-rod dystrophy. J Med Genet 2010;47:665-9.

Joensen P.
Multiple sclerosis incidence in the Faroe Islands 1986-2007. Acta Neurol Scand. 2010 May;121(5):348-53. Epub 2009 Dec 15. PMID: 20015109

Hjortshoj TD, Gronskov K, Brondum-Nielsen K, Rosenberg T.
A novel founder BBS1 mutation explains a unique high prevalence of Bardet-Biedl syndrome in the Faroe Islands. Br J Ophthalmol 2009;93:409-13.

Morava E, Steuerwald U, Carrozzo R, Kluijtmans LA, Joensen F, Santer R, Dionisi-Vici C, Wevers RA.
Dystonia and deafness due to SUCLA2 defect; Clinical course and biochemical markers in 16 children. Mitochondrion. 2009 Nov;9(6):438-42. Epub 2009 Aug 8.[http://www.ncbi.nlm.nih.gov/pubmed/19666145]

Wermuth L, Bech S, Petersen MS, Joensen P, Weihe P, Grandjean P.
Prevalence and incidence of Parkinson’s disease in The Faroe Islands. Acta Neurol Scand. 2008 Aug;118(2):126-31. Epub 2008 Feb 19. PMID: 18294341

Halling J, Weihe P, Brosen K.
CYP2D6 polymorphism in relation to tramadol metabolism: a study of faroese patients. Ther Drug Monit. 2008 Jun;30(3):271-5.

Halling J, Petersen MS, Grandjean P, Weihe P, Brosen K.
Genetic predisposition to Parkinson’s disease: CYP2D6 and HFE in the Faroe Islands. Pharmacogenet Genomics. 2008 Mar;18(3):209-12.

Halling J, Weihe P, Brosen K.
The CYP2D6 polymorphism in relation to the metabolism of amitriptyline and nortriptyline in the Faroese population. Br J Clin Pharmacol. 2008 Jan;65(1):134-8. Epub 2007 Aug 31.

Lund AM, Joensen F, Hougaard DM, Jensen LK, Christensen E, Christensen M et al.
Carnitine transporter and holocarboxylase synthetase deficiencies in The Faroe Islands. J Inherit Metab Dis. 2007.

Carrozzo R, Dionisi-Vici C, Steuerwald U, Lucioli S, Deodato F, Di Giandomenico S, Bertini E, Franke B, Kluijtmans LA, Meschini MC, Rizzo C, Piemonte F, Rodenburg R, Santer R, Santorelli FM, van Rooij A, Vermunt-de Koning D, Morava E, Wevers RA.
SUCLA2 mutations are associated with mild methylmalonic aciduria, Leigh-like encephalomyopathy, dystonia and deafness.Brain. 2007 Mar;130(Pt 3):862-74. Epub 2007 Feb 14.[http://www.ncbi.nlm.nih.gov/pubmed/17301081]

Ellefsen A, Kampmann H, Billstedt E, Gillberg IC, Gillberg C.
Autism in the Faroe Islands: an epidemiological study. J Autism Dev Disord. 2007;37:437-44.

Ostergaard E, Hansen FJ, Sorensen N, Duno M, Vissing J, Larsen PL et al.
Mitochondrial encephalomyopathy with elevated methylmalonic acid is caused by SUCLA2 mutations. Brain. 2007;130:853-61.

Als TD, Jorgensen TH, Borglum AD, Petersen PA, Mors O, Wang AG.
Highly discrepant proportions of female and male Scandinavian and British Isles ancestry within the isolated population of the Faroe Islands. Eur J Hum Genet. 2006;14:497-504.

Nolsøe RL, Bergholdt R, Deckert M, Róin J, Olsen SF, Kelly JA et al.
Identification of novel type 1 diabetes susceptibility loci in the Faroese population, a genetic isolate. Diabetologia. 2006;49 [Suppl 1]:177:0283.

Wang AG, Dahl HA, Vang M, Als TD, Ewald H, Kruse TA et al.
Genetics of panic disorder on the Faroe Islands: a replication study of chromosome 9 and panic disorder. Psychiatr Genet. 2006;16:99-104.

Halling J, Petersen MS, Damkier P, Nielsen F, Grandjean P, Weihe P, Lundgren S, Lundblad MS, Brøsen K.
Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population. Eur J Clin Pharmacol. 2005 Aug;61(7):491-7.

Joensen F, Steuerwald EU, Rasmussen NH.
Three congenital metabolic diseases in the Faeroe Islands. Incidence, clinical and molecular genetic characteristics of Faeroese children with glycogen storage disease type IIIA, carnitine transporter deficiency and holocarboxylase synthetase deficiency]. Ugeskr Laeger. 2006;168:667-70.

Fuchs J, Holm K, Vilhelmsen K, Rosenberg T, Scherfig E, Fledelius HC.
Hereditary high hypermetropia in the Faroe Islands. Ophthalmic Genet. 2005;26:9-15.

Als TD, Dahl HA, Flint TJ, Wang AG, Vang M, Mors O et al.
Possible evidence for a common risk locus for bipolar affective disorder and schizophrenia on chromosome 4p16 in patients from the Faroe Islands. Mol Psychiatry. 2004;9:93-98.

Jeganathan D, Chodhari R, Meeks M, Faeroe O, Smyth D, Nielsen K et al.
Loci for primary ciliary dyskinesia map to chromosome 16p12.1-12.2 and 15q13.1-15.1 in Faroe Islands and Israeli Druze genetic isolates. J Med Genet. 2004;41:233-40.

Fledelius HC, Fuchs HJ, Rosenberg T.
Oculometric characteristics of extreme hypermetropia in two faroese families. Optom Vis Sci. 2004;81:762-68.

Jorgensen TH, Buttenschon HN, Wang AG, Als TD, Borglum AD, Ewald H.
The origin of the isolated population of the Faroe Islands investigated using Y chromosomal markers. Hum Genet. 2004;115:19-28.

Caldovic L, Morizono H, Panglao MG, Cheng SF, Packman S, Tuchman M.
Null mutations in the N-acetylglutamate synthase gene associated with acute neonatal disease and hyperammonemia. Hum Genet. 2003;112:364-68.

Ewald H, Flint TJ, Jorgensen TH, Wang AG, Jensen P, Vang M et al.
Search for a shared segment on chromosome 10q26 in patients with bipolar affective disorder or schizophrenia from the Faroe Islands. Am J Med Genet. 2002;114:196-204.

Jorgensen TH, Degn B, Wang AG, Vang M, Gurling H, Kalsi G et al.
Linkage disequilibrium and demographic history of the isolated population of the Faroe Islands. Eur J Hum Genet. 2002;10:381-87.

Jorgensen TH, Borglum AD, Mors O, Wang AG, Pinaud M, Flint TJ et al.
Search for common haplotypes on chromosome 22q in patients with schizophrenia or bipolar disorder from the Faroe Islands. Am J Med Genet. 2002;114:245-52.

Bille M, Munk-Nielsen L, Tranebjaerg L, Parving A.
Two families with phenotypically different hereditary low frequency hearing impairment: longitudinal data and linkage analysis. Scand Audiol. 2001;30:246-54.

Santer R, Kinner M, Steuerwald U, Kjaergaard S, Skovby F, Simonsen H et al.
Molecular genetic basis and prevalence of glycogen storage disease type IIIA in the Faroe Islands. Eur J Hum Genet. 2001;9:388-91.

Older articles (Before 2000)

Ewald H, Wang AG, Vang M, Mors O, Nyegaard M, Kruse TA.
A haplotype-based study of lithium responding patients with bipolar affective disorder on the Faroe Islands. Psychiatr Genet. 1999;9:23-34.

Jantz RL.
Variation among European populations in summary finger ridge-count variables. Ann Hum Biol. 1997;24:97-106.

Joensen P.
ANNALES SOCIETATIS SCIENTIARUM FÆROENSIS SUPPLEMENTUM
No. XWII. 1992, Parts of Faroese Neuroepidemiology. FØROYA Fróðskaparfelag, Torshavn

Fledelius HC, Rosenberg T.
Extreme hypermetropia and posterior microphthalmos in three siblings. An oculometric study. In: Ossoinig KC, ed. Ophthalmic Echography. Dordrecht: Martinus Nijhoff/Junk; 1987: 87-91.

Joensen P.
Prevalence, incidence, and classification of epilepsy in the Faroes. Acta Neurol Scand. 1986 Aug;74(2):150-5. PMID: 3776461

Joensen P.
Subarachnoid hemorrhage in an isolated population. Incidence on the Faroes during the period 1962-1975. Stroke. 1984 May-Jun;15(3):438-40. PMID: 6729871 Free Article

Harvey RG, Suter D.
Digital dermatoglyphics of the Faroe Islanders. Am J Phys Anthropol. 1983;61:337-45.

Joensen P.
Stroke in an isolated population. Incidence on the Faroes during 1962-1975. Acta Med Scand. 1982;212(5):309-11. PMID: 7180581

Joensen P.
Incidence of primary intracranial neoplasms in an isolated population (the Faroes) during the period 1962-1975. Acta Neurol Scand. 1981 Jul;64(1):74-8. PMID: 7324874

Joensen HD, Hansen HE, Henningsen K, Svejgaard A, Andersen I.
A study of the linkage relations of epidermolysis bullosa dystrophica. Hum Hered. 1979;29:221-25.

Cohn J, Wang P, Hauge M, Henningsen K, Jensen B, Svejgaard A.
Amylo-1,60glucosidase deficiency (glycogenosis type III) in the Faroe Islands. Hum Hered. 1975;25:115-26.

Joensen HD.
Epidermolysis bullosa dystrophica dominans in two families in the Faroe Islands. A clinico-genetic study of 56 living individuals. Acta Derm Venereol. 1973;53:53-60.

Fog M.
The Shetland-Orkney-Faroe Project. Acta Neurol Scand. 1966;42:Suppl-8.